Can You Donate Blood if You Smoke Weed? Mango Cannabis Can you donate blood if you smoke? Vaping is as bad as smoking and it significantly decreases lifespan. Vaping contains ultrafine particles, volatile organic compounds and aldehydes that promote inflammation and damage heart and lungs. Here are scientific evidence Vaping, Venous Valves, and Vein Disease Smoking (or vaping) doesn't affect your ability to donate blood. Help us bust this myth by sharing our post. Can you donate blood if you smoke?