How VitE protects the RBCs membrane. RBCs = red blood cells, VitE = Download Scientific Diagram Storage lesion: History and perspectives Red & White Blood Cells Basicmedical Key Erythrocyte and plasma oxidative stress appears to be compensated in patients with sickle cell disease during a period of relative health, despite the presence of known oxidative agents ScienceDirect In RBCs, NADPH are produced exclusively via HMP shunt by the action of G6PD and are responsible to maintain membrane integrity preventing premature destruction. That is why G6PD deficient RBCs are Oxidative Stress in Healthy and Pathological Red Blood Cells