Venous Lake of Lip and Lip Freckle Removal with Iridex Laser Are Freckles on Lips a Cause for Concern? Causes, Remedies Dark Black Spot on Lip Dermatologist in Roorkee Oral melanoacanthoma and oral melanotic macule: a report of 8 cases, review of the literature, and immunohistochemical analysis Melanotic macule. Benign. Dark spot on labia (or lip). Analogous to lentigo simplex. Hyperpigmented basal keratinocytes & dermal melanophages. Slight in single basal melanocytes; NO nests. More info like this in Labial Macules: Dark Spots on the Lip Dermatology Advisor