Could Tylenol be making your child's health worse? Acetaminophen is widely used for pain and fever relief, but research suggests it depletes glutathione, a powerful antioxidant essential for immune function, Best Glutathione Supplement 4 Recommendations in 2026 Can Tylenol (acetaminophen) deplete glutathione levels in the body? Glutathione Collagen Whitening Formula, 500mg + Fast Absorption Vitamin C eBay Glutathione IV Detox Your Shortcut to Feeling Fabulous Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors.