Glutathione is such a critical soldier in our line of defense that our bodies make it themselves. We even have mechanisms that recycle and reuse it. But what happens when our toxic Glutathione Metabolism in Renal Cell Carcinoma Progression and Implications for Therapies Regulated cell death pathways in kidney disease Nature Reviews Nephrology Increase in renal glutathione in cholestatic liver disease is due to a direct effect of bile acids American Journal of Physiology Renal Physiology American Physiological Society Disruption in glutathione metabolism and altered energy production in the liver and kidney after ischemic acute kidney injury in mice Scientific Reports Repression of the antiporter SLC7A11 glutathione glutathione peroxidase 4 axis drives ferroptosis of vascular smooth muscle cells to facilitate vascular calcification Kidney International