Dihexa (also known as PNB 0408) is an experimental small molecule derived from angiotensin IV. It was engineered to cross the bloodbrain barrier and has shown synaptogenic effects in preclinical models. The often quoted Dihexa, 500 mg, CAS No. 1401708 83 5 Research Chemicals Biochemicals Product Expansion Campaign Carl ROTH International Illustrated Glossary of Organic Chemistry Hydrophobic effect A hydrophobic pocket Nature Synthesis WO2014052766A1 Hepatocyte growth factor mimics as therapeutic agents Google Patents Explained: Hydrophobic and hydrophilic MIT News Massachusetts Institute of Technology