Glutathione is a critical soldier in our line of defense. We even have mechanisms that recycle and reuse it. But what happens when our toxic burden becomes too high? Our genetic detoxification MTHFR and LC, CFS, POTS, MCAS, SIBO, EDS: Methylating the Alphabet Article (Preprint v1) by Patrick Chambers Qeios Glutathione responsive and mitochondria targeting enhanced photodynamic therapy and cascade triggered carbon monoxide release for all in one tumor therapy ScienceDirect Mast cells are hypersensitive immune cells that release histamine and other inflammatory mediatorsoften in response to oxidative stress, environmental toxins, and immune imbalance. Many patients with MCAS have low levels of glutathione. Glutathione: pharmacological aspects and implications for clinical use Geriatric Care The antioxidant glutathione ScienceDirect